Cause of Nasal polyps is Unknown ( Must Read )

The frequency of nasal polyps is uncertain. Only 0.5% of individuals with atopic symptoms manifest nasal polyposis, and most patients with diffuse nasal polyposis do not demonstrate an immunoglobulin E (IgE)–mediated type 1 hypersensitivity reaction. Patients with cystic fibrosis have a higher prevalence of nasal polyposis (up to 40%). In a study of 10,336 US adults, Palmer et al found that 11.5% of these individuals reported symptoms of chronic rhinosinusitis, with about 10% of this subgroup indicating that they had received a previous diagnosis of nasal polyps. 


Polyp development within nasal and sinus regions implicates an IgE-type hypersensitivity and an immunologic or possibly inflammatory basis for such formation.

The exact etiology of polyp formation is unknown. Research is demonstrating an eosinophil-mediated mechanism with damage to the mucosa by major basic protein, but the complicated interplay of secondary messengers and chemical mediators is not clear.

A retrospective case-control study by De Corso et al found that in a comparison of three sets of patients—those with persistent eosinophilic nonallergic sinonasal inflammation (n = 84), patients with neutrophilic inflammation (n = 106), and, as controls, patients with nonallergic noninfectious vasomotor rhinitis in whom nasal cytology revealed no evidence of inflammation (n = 105)—those in the eosinophilic group were most likely to develop nasal polyps. Specifically, 34.5% of the eosinophilic group developed nasal polyps, compared with 16.0% and 4.8% in the neutrophilic and control groups, respectively.


 

Nasal polyposis in association with cystic fibrosis, sinobronchial syndrome, aspirin sensitivity, and Samter triad (asthma, aspirin allergy, nasal polyposis) indicates manifestation of nasal mucosal damage by many different possible disease processes.

Read more :  How to Treat Nasal Polyps Naturally at Home ?

 

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What are Causes of Nasal Polyps ?

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  Chronic rhinosinusitis with nasal polyps (CRSwNP) affects about 4% of the European population.1 It is characterized by nasal obstruction, loss of smell, nasal secretions, and facial pressure. About 50% of these patients have comorbid asthma, aspirin-exacerbated respiratory disease, hypereosinophilia, or Churg-Strauss syndrome. Recurrence of the disease after surgery is high despite treatment with topical and oral glucocorticosteroids. A growing amount of evidence linking local IgE production to inflammation in patients with Nasal Polyps can be seen in the literature. Previous studies showed that specific and total IgE concentrations are increased in nasal polyps compared with those in serum or nonpolyp mucosa, illustrating an association between increased total IgE level and eosinophilic inflammation.Further studies from  independent groups also showed increased specific IgE levels in sinus tissue of patients with Nasal Polyps and greater IgE concentrations in the sinus mucosa of pat
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How to Cure Nasal Polyps without Surgery ?

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Nasal polyposis is an inflammatory condition of unknown etiology. Nasal polyps are the most common tumors of the nasal cavity. Approximately 30% of patients with nasal polyps test positive for environmental allergies.  Patients with massive nasal polyposis typically present with increasing nasal congestion, hyposmia to anosmia, changes in sense of taste, and persistent postnasal drainage. Headaches and facial pain and discomfort are not uncommon and are found in the periorbital and maxillary regions. On occasion, a patient with completely obstructing nasal polyposis presents with symptoms of obstructive sleep apnea.  Patients with solitary polyps frequently present with only symptoms of nasal obstruction, which may change with a shift in position. Coronal sinus CT scanning is the imaging study of choice in the evaluation of patients with nasal polyposis. Endoscopy in an office setting can sometimes be helpful in the diagnosis and evaluation o
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Is Surgery Necessary for Nasal Polyps ?

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What is Nasal Polyps ?   Nasal polyposis results from chronic inflammation of the nasal and sinus mucous membranes. Chronic inflammation causes a reactive hyperplasia of the intranasal mucosal membrane, which results in the formation of polyps. The precise mechanism of polyp formation is incompletely understood. In 1990, Tos reported 10 pathogenic theories of nasal polyp formation. Multiple chemical mediators have been identified in nasal polyps but their significance has not been completely elucidated. Some of these mediators may be released by the polyps themselves and others by the eosinophils found in certain subsets of polyps. Cysteinyl leukotriene receptors and interleukin-5 (IL-5) appear to be the most well studied. Patients with chronic allergic rhinitis; chronic sinusitis; and, less frequently, underlying disease, such as cystic fibrosis, may be at risk for the development of nasal polyps. Common presenting symptoms include nasal obstruction; chronic rh
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